Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Orodispersible tablets are the fast growing and highly accepted drug delivery system in now a days mainly to improve patient compliance. Orodispersible tablets have number of advantages over conventional dosage forms, because of that Orodispersible tablets have emerged as an alternative to conventional dosage forms. Orodispersible tablets dissolve or disintegrates instantly on the patient tongue or buccal mucosa. It is suited for tablets undergoing high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to minimize side effect and make it more cost effective. This study was aimed, which can disintegrate or dissolve rapidly once placed in the oral cavity. Propranolol hydrochloride is a Antihypertensive drug, which undergoes extensive hepatic degradation (96%), which have poor Oral bioavailability (26%) for overcoming this problem Orodispersible tablets of Propranolol hydrochloride can be formulated which avoids extensive first pass metabolism and improvement in dissolution efficacy, disintegration time which results in improvement in bioavailability. The advantage of this formulation is such that in case of hypertension attack patient can take the drug without the usage of water. Therefore the main objective of the present work is to develop orodispersible tablets of Propranolol hydrochloride to improve bioavailability, disintegration time, dissolution efficacy and patient compliance.
Key words: superdisintegrants, orodispersible tablets, disintegration time, direct compression.
Article No 6
February - 2011 / Volume - 2 / Issue - 12 / Article No -6 / Research Article
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF PROPRANOLOL HYDROCHLORIDE
Deshpande Kiran Bhaskar1*, More M. R.1 ,
G. N.Sockan1 , Kunchu K.1 , Tamiz Mani1 .
1Department of Pharmaceutics,
Bharathi College of Pharmacy, Bharathinagara,
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue