Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
It is found that scientists are now only beginning to comprehend the complexity of transdermal drug delivery. Elucidation of the biochemical composition and functioning of the intrinsic diffusion barrier of the stratum corneum has prompted investigation of chemical and physical means of enhancing the percutaneous penetration of poorly absorbed drugs. A popular approach for improving transdermal drug delivery involves the use of penetration enhancers (sorption promoters or accelerants) which penetrate into skin to reversibly reduce the barrier resistance. The use of chemical penetration enhancers would significantly increase the number of drug molecules suitable for transdermal delivery like terpenes present in naturally occurring volatile oils appear to be clinically acceptable enhancer. The purpose of this review was to compile the naturally used percutaneous permeation enhancers for topically used or transdermal delivery system.
Key words: Enhancer; Stratum corneum; Lipid; Barrier; Skin; Transdermal
Article No 5
February - 2011 / Volume - 2 / Issue - 12 / Article No - 5 / Review Article
TERPENES: NATURAL SKIN PENETRATION ENHANCERS IN TRANSDERMAL DRUG DELIVERY SYSTEM
Daleshwari Lahora1*, Vandana Chaudhary3,
Saurabh Kumar Shah1, Gaurav Swami2
Giridhari Chaudhary4 , Shubhini A. Saraf5
1NIMS Instutute of Pharmcy, Jiapur
2Bharti Institute of Pharmaceutical Sciences,
Sri Ganganagar, Rajasthan
3CT Institute of Pharmaceutical Sciences, Jalandhar, Punjab
4Guru Gobind Singh College of Pharmacy, Yamuananagar
5Ranbxy Pvt Ltd, New Delhi
6 BBDNITM, Lucknow
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue