ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
Gastric emptying is a very complex and uncertain process which sometime alters the in vivo performance of the drug delivery systems. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 hours. The floating or hydrodynamically controlled drug delivery systems are useful in such application. The main purpose of writing this review on floating drug delivery systems (FDDS) is to correlate and compile the recent literature on the principal mechanism and working of floatation to achieve gastric retention. There are various recent developments and findings of FDDS including the physiological and formulation variables affecting gastric retention. Also there are various approaches to design single-unit and multiple-unit floating systems with their classification and formulation aspects. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems, and applications of these systems. Floating drug delivery system, are useful for various problems encountered during the development of a pharmaceutical dosage form.



Key words:
Floating drug delivery system, Gastric retention, Bioavailability.
Article No 4
February - 2011 / Volume - 2 / Issue - 12 / Article No - 4 / Review Article

FLOATING MICROSPHERES:  A PROMISING APPROACH FOR GASTRIC RETENTION


Chetan Patil1*
, Sunil Bakliwal1, Bhushan Rane1,
Nayan Gujarathi1, Sunil Pawar1

1Department of Quality Assurance,
P.S.G.V.P.Mís College of Pharmacy, Shahada,
Dist. Nandurbar- 425409, Maharashtra, India.
Email : patilc58@yahoo.co.in
Chetan Patil
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue
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