ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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January - 2010 / Volume - 2/Issue - 11
( Total Articles =15 )
January 2011 Issue
ABSTRACT
  
  
In the present study, an attempt has been made to evaluate the effect of hydrophilic polymers on the release profile of drug from matrix system. Salbutamol sulphate, an anti-asthmatic agent, was used as a model drug to evaluate its release characteristics from different matrices. Matrix tablets of salbutamol sulphate were prepared by direct compression process using methocel K100M CR polymer. Release kinetics of salbutamol sulphate from these sustained release matrices in distilled water using USP paddle method with sinker for 8 hours were studied. Statistically significant differences were found among the drug release profile from different formulations. Higher polymer content (70%) in the matrix decreased the rate of the drug due to increased tortuosity and decreased porosity. At lower polymeric level (30%), the rate of drug release was elevated. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer equations. The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer level and physico-chemical properties of the drug.


Key words:
Salbutamol sulphate, methocel K100M CR, matrix tablets, sustained release
Article No 14
December - 2010 / Volume - 2 / Issue - 10 / Article No - 14 / Research Article

DEVELOPMENT AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF SALBUTAMOL SULPHATE USING METHOCEL K100M CR POLYMER

Md. Mofizur Rahman2*
, Md. Qamrul Ahsan1
,Mithilesh Kumar Jha2, 
Ishtiaq Ahmed3, Md. Mizanur Rahman Moghal 3,
Md. Habibur Rahman3

1Department of Pharmacy, University of Asia Pacific,
Dhaka, Bangladesh,
2
Department of Pharmacy, Bangladesh University,
Mohammadpur, Dhaka-1207, Bangladesh,
3Department of Pharmaceutical Technology, University of Dhaka,
Dhaka -1000
Email:rmfi02@yahoo.com
Mofizur Rahman
Only 15 Articles will be Published in Each Issues