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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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January - 2010 / Volume - 2/Issue - 11
( Total Articles =15 )
January 2011 Issue
ABSTRACT

   As a part of systematic  investigation of synthesis  and  biological activity   of several new 2-[2-{2-(substitutedphenyl)-4-oxo-1,3-thiazolidin}-5-methyl-1,3,4-thiadiazol]-imino-4-phenyl-1,3-thiazole, 5(a-n) and 2-[2-{2-(substitutedphenyl)-4-oxo-5-(sustitutedbenzyliden)-1,3-thiazolidin}-5-methyl-1,3,4-thiadiazol]-imino-4-phenyl-1,3-thiazole, 6(a-n) were synthesized from 2-{2-(substitutedbenzyliden)-imino-5-methyl-1,3,4-thiadiazol}-imino-4-phenyl-1,3-thiazole, 4(a-n) using 2-amino-4-phenyl-1, 3-thiazole as a starting material. The synthesized compounds have been screened in vitro for their antimicrobial activity against B. subtilis, E. coli and S. aureus bacteria and A. niger, A. flavus, and C. albicans fungi respectively. Some of the compounds displayed pronounced biological activity.


Key words:
Synthesis, thiazole, 4-oxo-thiazolidine, antimicrobial activity.
Article No 11
January - 2011 / Volume - 2 / Issue - 11 / Article No - 11 / Research Article

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF THIAZOLIDINE DERIVATIVES OF THIAZOLE


Smita Verma 1*,
S.K. Srivastava2,Pushkal Samadhiya2

1Department of Chemistry, Govt. P.G. College,
Damoh (M.P.) 470661, India
2
Synthetic Organic Chemistry Laboratory,
Department of Chemistry,
Dr. H.S. Gour University (A Central University),
Sagar (M.P.), 470003, India
Emailsmita_priti@rediffmail.com
Smita Verma
Only 15 Articles will be Published in Each Issues