Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
January - 2010 / Volume - 2/Issue - 11
( Total Articles =15 )
January 2011 Issue
Macrotyloma uniflorum belongs to the family Fabaceae. It is one of the lesser known beans. It is used as food and fodder. The current aim of our research work is to isolate bio-binder from the seeds of Macrotyloma uniflorum, evaluate for relevant properties and used it as a bio-binder to prepare ciprofloxacin tablets. The bio-material from the seeds was isolated by simplified economic process. The isolated biomaterial was subjected to various physico-chemical tests like solubility, color changing point and pH. The ciprofloxacin hydrochloride granules were prepared using 1 - 5% biomaterial as a bio-binder. The prepared tablets were evaluated for hardness, friability, weight uniformity, disintegration and dissolution profiles. Ciprofloxacin tablets containing starch mucilage as standard binder were produced and assessed comparatively. Our research result reveals that the formulated tablets using bio-material shows significant properties comparative to standard tablets prepared using starch.
Key words: Macrotyloma uniflorum, bio-binder, ciprofloxacin hydrochloride.
Article No 10
January - 2011 / Volume - 2 / Issue - 11 / Article No - 10 / ResearchArticle
FORMULATION AND EVALUATION OF CIPROFLOXACIN TABLET USING A NOVEL BIO-BINDER FROM MACROTYLOMA UNIFLORUM
Sayantan Mukhopadhyay *1,
N.V. Satheesh Madhav 2,
1Dept of pharmacy, GRD (PG) Institute of
management & technology, Dehradun, Uttrakhand,India.
2Novel Drug Delivery Research Laboratory, DIT,
Faculty of Pharmacy, Dehradun, Uttrakhand,India.
3Dept. of Pharmacognosy, Kumaun University,
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