Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
January - 2010 / Volume - 2/Issue - 11
( Total Articles =15 )
January 2011 Issue
Oral sustained release dosage forms are the most commonly formulated but still offer highest attention in the area of novel drug delivery systems. (1-2). This system can also help in optimizing oral controlled delivery of drugs having ‘absorption window’ by continuously releasing drug prior to absorption window, for prolonged period of time thus causing optimal bioavailability (3). Gastric emptying of dosage forms is an extremely variable process and ability to prolong and control the emptying time is a valuable asset for dosage forms, which reside in the stomach for a longer period of time than conventional dosage forms (4). Prolonged gastric residence time (GRT) and controlled release of drugs within the GI tract helps to reduce dosing frequency and total dose, improve patient compliance and convenience, maintain a less fluctuating plasma level, as well as reduce GI side effects. Prolonging the GRT of therapeutic agents is thought to be beneficial especially under several circumstances such as for drugs acting topically on the gastric region, for drugs with a narrow therapeutic window or for drugs with the major absorption site in the upper GI tract (5-6).
Key words: novel drug delivery systems,absorption window,Prolonged gastric residence time,optimizing oral controlled delivery etc.
Article No 4
January - 2011 / Volume - 2 / Issue - 11 / Article No - 4 / Review Article
NOVEL SUSTAINED RELEASE GASTRORETENTIVE DRUG DELIVERY SYSTEM
: A REVIEW
Ramdas T. Dolas1*,Dr. Avinash Hosmani 2,
Brijesh Kumar1,Sachin Somvanshi3
1Jodhpur National University, Jhanwar Road,
Boranada, Jodhpur, Rajasthan.
2Government College of Pharmacy, Karad
, Maharashtra, India
3P.R.E.S’s College of Pharmacy, Chincholi, Sinnar,
Nashik, Maharashtra, India
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