Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
January - 2010 / Volume - 2/Issue - 11
( Total Articles =15 )
January 2011 Issue
Khaya gum gotten from the bark of khaya senegalensis was used as disintegrant in chloroquine phosphate tablets and was evaluated and compared to maize starch and microcrystalline cellulose. Batches of 5, 7.5 and 10%w/w were formulated for the three excipients.Khaya gum was observed to swell to about ten (10) times its weight in water. The granules of all the batches were observed to have good flow properties. Tablets of all the batches containing khaya gum were observed to be softer, disintegrated faster and had greater dissolution than the tablets of the MCC batches. An increase in the concentration of the khaya gum led to slower disintegration of the tablets. The dissolution profile showed that an increase in the concentration of khaya gum led to a retardation in the release of the drug and the effective concentration for fast disintegration and quick drug release was found to be 5%w/w. The mechanism of disintegration and drug release was attributed to the gumís water uptake and swelling capacity.
Key words: Disintegrant, gum, khaya senegalensis, chloroquine phosphate.
Article No 2
January - 2011 / Volume - 2 / Issue - 11 / Article No -2 / Research Article
EFFECT OF CONCENTRATION ON THE RELEASE PROPERTY OF KHAYA SENEGALENSIS GUM IN CHLOROQUINE PHOSPHATE TABLET FORMULATION.
Olubunmi J. Olayemi1*,
Oluranti Abolude1, Halima-Sadia Mahmud1
1Department of Pharmaceutics and
Pharmaceutical Microbiology, Ahmadu Bello University,
Only 15 Articles will be Published in Each Issues