ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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December - 2010 / Volume - 2/Issue - 10
( Total Articles =18 )
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December 2010
ABSTRACT

  Today, many doctors have changed their approach, especially for patients with severe, rapidly progressing rheumatoid arthritis. Studies show that early treatment with more powerful drugs, and the use of drug combinations instead of one medication alone, may be more effective in reducing or preventing joint damage. Once the disease improves or is in remission, the doctor may gradually reduce the dosage or prescribe a milder medication. Some medications are used only for pain relief; others are used to reduce inflammation. Still others, often called Disease-Modifying Antirheumatic drugs (DMARDs), are used to try to slow the course of the disease. Biologic response modifiers are new drugs used for the treatment of rheumatoid arthritis. Current article highlights the important aspect of Rheumatoid arthritis, special emphasis on its therapy majorally DMARDs, Biological agents and the growing use of DMARDs, Biological agents v/s Analgesics and Nonsteroidal Anti-inflammatory Drugs (NSAIDs).

        

Key words:
DMARDs, Biological agents, NSAIDs, Rheumatoid Arthritis (RA)
Article No 18
December - 2010 / Volume - 2 / Issue - 10 / Article No - 18 / Research Article

DMARDíS AND BIOLOGICAL AGENTS: THE SECOND LINE TREATMENT FOR RHEUMATOID ARTHRITIS


Rakesh D.Amrutkar*1,

Pravin S. Khairnar1, Rajendra S. Bhambar1

1M.G.VíS S.P.H. College of Pharmacy,
L.V.H Marg, Malegaon camp,
Malegaon - 423105, (Nashik), Maharashtra, India.
     Email:pankajnariya@yahoo.co.in
Rakesh Amrutkar