Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
December - 2010 / Volume - 2/Issue - 10
( Total Articles =17 )
December 2010 Issue
Article No 16
December - 2010 / Volume - 2 / Issue - 10 / Article No - 16 / Research Article
ANTICONVULSANT ACTIVITY OF GLYCYRRHIZIC ACID IN MICE
Kale Shubhangi.S1*., Shete Rajkumar.V1.,
Kore Kakasaheb.J.1,Patil Bhaskar.M.1,
Bhutada Rupesh.N.1, Pattankude Vinod.S.1
1Department of Pharmacology , Rajgad Dnyanpeeth’s
College of Pharmacy Bhor, (Pune)
M.S. India -412206.
This investigation has been carried out to evaluate Glycyrrhizic acid, ammonium salt for its anticonvulsant effect. It is chemically pentacyclic triterpenoid saponin glycoside belonging to ß-amyrin series. It’s ammonium salt is water soluble above pH 4.5.This salt enhances the activity of Glutamate transaminase. Literature survey has shown that no work has been carried out to evaluate anticonvulsant action of Glycyrrhizic acid and also shown that the toxicological studies of monoammonium salt of Glycyrrhizic acid has no side effects when administered in mice and rats .
The convulsions were evoked by Pentylenetetrazole (80mg/Kgs.c) and Isoniazid (300mg/Kg s.c). Systemic administration (i.p) of 100, 200, 300, 400 mg/Kg dose of Glycyrrhizic acid was able to delay the onset of convulsions and death in dose dependent manner.
The results were found to be significant with p-Values for Pentylenetetrazole and Isoniazid induced convulsions as 0.001 and 0.002 respectively as compared to vehicle treated group and thus glycyrrhizic acid possess anticonvulsant action.
Key words: Convulsions, PTZ, Isoniazid, Diazepam, Glycyrrhizic acid, ammonium salt.