ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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December - 2010 / Volume - 2/Issue - 10
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December 2010
Article No 16
December - 2010 / Volume - 2 / Issue - 10 / Article No - 16 / Research Article

ANTICONVULSANT ACTIVITY OF GLYCYRRHIZIC ACID IN MICE


Kale Shubhangi.S1*.
, Shete Rajkumar.V1.,
Kore Kakasaheb.J.1,Patil Bhaskar.M.1,
Bhutada Rupesh.N.1, Pattankude Vinod.S.1


1Department  of  Pharmacology , Rajgad Dnyanpeeth’s
College of Pharmacy Bhor, (Pune)       
M.S. India -412206.
Email:pawar7shubhangi123@rediffmail.com
   
Shubhangi Kale
ABSTRACT

  This  investigation  has  been  carried  out  to  evaluate  Glycyrrhizic  acid, ammonium  salt  for  its  anticonvulsant  effect. It  is  chemically  pentacyclic   triterpenoid  saponin  glycoside  belonging  to  ß-amyrin  series. It’s  ammonium  salt  is  water  soluble  above  pH 4.5.This  salt  enhances  the  activity  of  Glutamate  transaminase. Literature  survey  has  shown  that  no  work  has  been  carried  out  to  evaluate  anticonvulsant  action  of  Glycyrrhizic  acid  and  also  shown  that  the   toxicological  studies  of  monoammonium  salt  of  Glycyrrhizic  acid  has  no  side effects   when   administered  in  mice  and  rats .
The  convulsions  were  evoked  by  Pentylenetetrazole  (80mg/Kgs.c)  and  Isoniazid (300mg/Kg s.c). Systemic  administration  (i.p)  of  100,  200,  300,  400  mg/Kg  dose  of  Glycyrrhizic  acid  was  able  to  delay  the  onset  of  convulsions  and  death  in   dose  dependent  manner.
   The  results  were  found  to  be  significant  with   p-Values  for  Pentylenetetrazole and  Isoniazid  induced   convulsions  as  0.001  and  0.002  respectively  as  compared  to  vehicle  treated  group  and  thus  glycyrrhizic  acid  possess  anticonvulsant  action.

        

Key words:
Convulsions, PTZ, Isoniazid, Diazepam, Glycyrrhizic acid, ammonium salt.