Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
December - 2010 / Volume - 2/Issue - 10
( Total Articles =17 )
December 2010 Issue
Article No 14
December - 2010 / Volume - 2 / Issue - 10 / Article No - 14 / Review Article
THALASSEMIA : A REVIEW
S. R. Ghodekar1*,
N. D. Grampurohit1, S. S. Kadam1, R. M.Thorat1
1Vishal Institute of Pharmaceutical
Education And Research, Ale, Pune-412411.
Thalassemia is the name of a group of genetic blood disorders characterized by anemia due to enhanced red blood cell destruction.
Hemoglobin, the oxygen-carrying component of the red blood cells consists of two different proteins, an and a . If the body doesn't produce enough of either of these two proteins, the red blood cells become defective and cannot carry sufficient oxygen. The resulting anemia is usually severe with several health problems like enlarged spleen, bone deformities, fatigue and requires regular life-long transfusion, therapy and medical supervision.
Thalassemias can't be prevented because they're inherited, "inherited" means they are passed on from parents to children. However, these bleeding disorders can be found before birth through prenatal tests.
Thalassemia is a common inherited disease in the world. India accounts for 10% of the total world thalassemia population and approximately 1 in 30 in the general population is carrier of the mutated gene and the cases may increase as it is a hereditary disorder.
So, it is important to take into consideration about this disorder as it may prove deadly one. And thus the intensity of this disorder can be lowered by diagnosing and taking proper treatments.
Key words: Thalassemia, Haemoglobin, Globin Chains, Chromosome 11 & Chromosome 16.