Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
December - 2010 / Volume - 2/Issue - 10
( Total Articles =17 )
December 2010 Issue
Article No 13
December - 2010 / Volume - 2 / Issue - 10 / Article No - 10 / Research Article
ANTIULCER EFFECT OF LIVINA, A HERBAL FORMULATION AGAINST ETHANOL INDUCED ACUTE GASTRIC ULCER IN MICE
Dr. Soumendra Darbar1*,
1Research and Development Division,
Dey’s Medical Stores (Mfg.) Ltd.,
62, Bondel Road, Kolkata-700019, West Bengal, India
Dr. S. Darbar
Peptic ulcer is the most common GIT disorder in the present day life of the industrialized and civilized world. The prevention or cure of peptic ulcers is one of the most important challenges confronting medicine nowadays, as it is certainly a major illness affecting 8 to 10% of the global population and of these 5% suffer from gastric ulcer. This study was designed to evaluate the gastro protective effect of Livina, a polyherbal formulation on ethanol (50%) induced gastric ulcers in mice. Forty young white male Swiss albino mice were divided to five groups (8 mice/group). Three case groups received Livina (50, 100, 200 mg/kg) and control negative and positive groups received distilled water and ranitidine respectively. Animals were killed and their stomachs were removed and macroscopic and microscopic ulcer index were determined. Data were subjected to one-way ANOVA followed by Dennett’s t-test. The results indicated that polyherbal formulation, Livina (50,100,150 mg/kg) significantly decreased the ulcer index (p<0.05) and these doses of formulation exerted macroscopic curative ratios of 67.63%, 75.11% and 81.09% respectively. However, Livina at doses of 100 and 200 mg/kg significantly (P< 0.05) showed an antiulcer effect characterized by reduction of acid volume (AV), free acidity (FA), total acidity (TA), and increasing rate of pH, when compared to the control group. The present findings demonstrate that, Livina has gastroprotective effect on ethanol-induced gastric ulcer in mice model.
Key words: Gastric ulcer, Livina, Free acidity, mucosal damage