ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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December - 2010 / Volume - 2/Issue - 10
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December 2010
Article No 12
December - 2010 / Volume - 2 / Issue - 10 / Article No - 10 / Research Article

STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS   ESTIMATION OF AMBROXOL HYDROCHLORIDE AND ROXITHROMYCIN IN BULK AND TABLET  DOSAGE FORM

Dhiraj S.Nikam1*
, Swapnil C.Aswale1


1Department of  Pharmaceutical  Chemistry,
School of Pharmacy Technology Management,
Babulde, Shirpur, Dhule, M.S., India  425 405
Email:nikam_dhiraj@rediffmail.com

Dhiraj S. NIkam
ABSTRACT

A stability  indicating  reverse  phase  high  performance  liquid  chromatographic  method  is  developed  for  simultaneous  estimation  of  ambroxol  hydrochloride  and  roxithromycin  in  bulk  and  pharmaceutical  formulation.The  separation  is  made  by  phenomenex  Gemini  C18  column  (250 cm 4.6 mm, 5 m)  using  water: acetonitrile: orthophosphoric acid  (50:50:0.1)  as  a  mobile  phase. Detection  is  carried  out  at   210 nm. The  retention  time  of  ambroxol  hydrochloride  and  roxithromycin  is  2.33  and  4.22 min, respectively.   The  validation  of  the  method  is  performed  according  to  International  Conference  on  Harmonization  ICH Q2B  guideline. Specificity, reproducibility, precision  and  accuracy  are  confirmed. The  limits  of  quantification  are  approximately  0.75 g/ml  for  ambroxol  hydrochloride and  1.93 g/ml  for  roxithromycin. Due  to  simplicity  and  accuracy  the  method  particularly  suitable  for  routine  pharmaceutical  quality  control.



        

Key words:
RP-HPLC, ambroxol  hydrochloride,  Roxithromycin,stability-indicating.