Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
December - 2010 / Volume - 2/Issue - 10
( Total Articles =17 )
December 2010 Issue
Article No 10
December - 2010 / Volume - 2 / Issue - 10 / Article No - 10 / Review Article
IN VIVO AND IN VITRO ANTI-BACTERIAL EFFICACY OF ALTERNANTHERA SESSILIS (LINN.)
Dr. Johnson M1*, Wesely EG2, Selvan N3,
1Department of Plant Biology and Plant Biotechnology,
St. Xavier’s College (Autonomous),
Palayamkottai, Tamil Nadu, India
2 Department of Botany, Arignar Anna Government
Arts College, Namakkal, India
3 Centre for Biotechnology,
Muthayammal College of Arts & Science, Rasipuram,India
Dr. Johnson M.
The present study was under taken to compare the antibacterial potential of leaves, inter-nodal segments, leaves and inter-nodal segments derived calli of Alternanthera sessilis (Linn.) R.Br. ex DC. Maximum percentage of callus formation (inter-nodal segments 88.9 ± 0.83; leaves segments 92.4 ± 0.61) was obtained on Murashige and Skoog’s basal medium supplemented with 3% sucrose and 0.5 mg/l of 2, 4 - Dichlorophenoxy acetic acid. Dried whole plants as also the in vitro derived callus were powdered using the electric homogenizer exhaustively extracted by cool extraction with ethanol, Ethyl acetate, petroleum ether and water for 72 h. Antimicrobial activity was determined against four bacterial pathogens by the agar disc diffusion assay. The antibacterial effect of the leaves, inter-nodal, leaves and inter-nodal segments derived calli of A. sessilis was evaluated against Proteus vulgaris, Streptococcus pyogenes, Bacillus subtilis and Salmonella typhii. The ethanolic extracts of leaves and leaves derived calli were more effective against the selected bacteria than other and solvents.
Key words: In vitro, In vivo, Bio- efficacy, Anti-bacterial, Callus