Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
December - 2010 / Volume - 2/Issue - 10
( Total Articles =17 )
December 2010 Issue
Article No 9
December - 2010 / Volume - 2 / Issue - 10 / Article No - 9 /Research Article
ANTI-DIABETIC SCREENING LEAVES EXTRACT OF HOLOPTELEA INTEGRIFOLIA (ROXB.)
Sonu Sharma1*, Pankaj Khatri1,
Anupriya Pandey1, Vaibhavi Jakhetia1,
Lavlesh Chaturvedi2, Neelesh Dwivedi2
1Deapartment of Pharmacognosy;
Suresh Gyan Vihar University,Jaipur ( Raj.)
2Depertment of Medicinal Chemistry & pharmacognosy;
Daksh Institute of Pharmaceutical Sciences, Chhatarpur (M.P.)
Various parts of Holoptelea integrifolia, a roadside plant, are indicated by Charaka Samhitha Sushrutha and other traditional systems for the treatment of inflammation, acid gastritis, Dyspepsia, Flatulence, Colic, Intestinal Worms, Vomiting, Wounds, Vitiligo, Leprosy, Filariasis, Diabetes, Hemorrhoids, Dysmenorrhoea and rheumatism. According to literature survey, the plant Holoptelea integrifolia Roxb. exhibits a wide range of biological activities which have been reported by many workers. These all activities are subjected to further studies aimed at developing a promising pharmaceutical candidate for preclinical and clinical trials. On the basis of Ethnomedicinal uses of my plant I have selected anti diabetic activity because not sufficient study have been reported yet, in literature survey, so to test the activities of my plant extract I have selected this activity. The present study was aimed at pharmacological evaluation of Holoptelea integrifolia leaves. Methanol, Petroleum ether extract of leaves of Holoptelea integrifolia (Roxb.) was screened for Antidiabetic activity.Anti diabetic was compared with standard drug with Gliibenclamide for Alloxan induced method. In all method both extract showed better results statistical significances.
Key words: Methanol, Petroliun ether, Antidiabetic, Glibenclimide, Holoptelea, integrifolia, haemorrhoeds, vitiligo,dyspepsia, dysmenorrhoea.