ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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December - 2010 / Volume - 2/Issue - 10
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December 2010
Article No 8
December - 2010 / Volume - 2 / Issue - 10 /Article No - 08/ Research Article

ROSIGLITAZONE MALEATE MICROSPHERES FOR EXTENDING DRUG RELEASE: FORMULATION AND EVALUATION




Ram Chand Dhakar1*
,Sunil K. Prajapati1
Sheo Datta Maurya2,Anish K. Gupta3,
Girish K. Yadav4,Girija Dangi5

1Institute of Pharmacy, Bundelkhand University, Jhansi, India-284128
2Dept. of Pharmacy, IEC-CET, KP-I, G. Noida, India -201308
3Dept. of pharmacy, LIMT, KP-II, G. Noida, India -201308
4R&D Centre, MAPPL, Phase-2, Noida, India -201301
5Dept. of Pharmacy, GIET, Nathdwara, Udaipur, India-313301
Email:dhakar_rc@yahoo.co.in
Ram C. Dhakar
ABSTRACT

   The work was aim to formulate and evaluate mucoadhesive microspheres of Rosiglitazone Maleate for treatment of diabetes type-2 by combine the potential advantages of mucoadhesion with controlled drug delivery using various ratio of polymers. Mucoadhesive microspheres were prepared by emulsification solvent evaporation techniques. Microspheres were found discrete, spherical and free flowing. They ranged in particle size from 21-37 m. The microspheres exhibits good mucoadhesive property in in-vitro wash off test and showed high drug entrapment efficiency. Rosiglitazone Maleate release from these microspheres was slowed, extended and depended on the type of polymer used. The formulation F1 and F2 showed consistent drug release for up to 12 h time period. Among all the formulations, F1 containing sodium carboxy methyl cellulose and F2 containing Carbopol 934 showed the reproducible results with best mucoadhesive profile and good surface morphology. The work has demonstrated that among all the formulations of microspheres, particularly those of formulation F1 are promising candidates for the sustained release of Rosiglitazone Maleate in the gastrointestinal tract.




        

Key words:
Rosiglitazone Maleate, Mucoadhesive Microspheres, Diabetes Type-2, controlled drug delivery, Sodium carboxy methyl cellulose, Carbopol 934.