ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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December - 2010 / Volume - 2/Issue - 10
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December 2010
Article No 7
December - 2010 / Volume - 2 / Issue - 10 / Article No - 7 / Research Article

DEVELOPMENT OF NEW SPECTROPHOTOMETRIC METHODS FOR THE QUANTITATIVE DETERMINATION OF RIFABUTIN IN PHARMACEUTICAL FORMULATIONS


Dr. Medikondu Kishore1*,

M.Jayaprakash2, T.Vijayabhaskara Reddy3

1Department of Post-Graduation Chemistry,
S.V.R.M College and Research center,
Nagaram, Guntur (District), Andhra Pradesh, India-522268
2Executive, NatcoResearchCentre, B-13,
IndustrialEstate,Sanathnagar,Hyderabad
Andhra Pradesh, India-500018
3Jr.Manager, QualityAssurance, Dr Reddy’s Laboratories,
Bachupally - FTO-III, Hyderabad Andhra Pradesh, India.
Email:sinikaranayil@gmail.com
Medikondu Kishore
ABSTRACT

  Rapid, accurate, precise and specific colorimetric methods were developed for the determination of Rifabutin in pharmaceutical formulations and in bulk drugs. These methods was based on the quantitative precipitation of RFB with iodine (first step) and estimating the unreacted iodine in the filtrate with PMAP-SAc (second step) (M1) and the second method involves quantitative precipitation of drug with TA under acid conditions (first step) and estimating the unreacted tannic acid in the filtrate with PMAP-Cr (VI) at pH 3.0 (second step) (M2). The absorbance was measured at 520 and 460 nm for M1and M2respectively and the calibration curve was linear in the concentration range of 25-150 ?g/ml, 10-60 ?g/ml. The molar absorptivity was found to be 8.862x104, .625X103 .mol/and Sandellfs sensitivity of 0.6155 & 0.3012 per 0.001 absorbance unit (M1and M2). The color is stable for 5-48 (M1and M2) minutes after the reaction. The proposed methods were successfully extended to pharmaceutical preparations-capsules.

        

Key words:
Rifabutin, Spectrophotometric methods, Precipitation reactions, Quantitative estimation, statistical analysis