ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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December - 2010 / Volume - 2/Issue - 10
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December 2010
Article No 5
December - 2010 / Volume - 2 / Issue - 10 / Article No - 5 / Review Article

CHALLENGES IN THE FORMULATION OF BILAYERED TABLETS - A REVIEW


Patel Mehul
1*,
Ganesh Nanjan Sockan1, kavitha, Tamizh Mani1


1Department of pharmaceutics,
Bharathi College of Pharmacy
Bharathinagara, Mandya, Karnataka - 671 422
Email: mppharm@yahoo.co.in
Mehul Patel
ABSTRACT

  Several pharmaceutical companies are currently developing bi-layer tablets, for a variety of reasons: patent extension, therapeutic, marketing to name a few. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. This article explains why the development and production of quality bi-layer tablets needs to be carried out on purpose-built tablet presses to overcome common bi-layer problems, such as layer-separation, insufficient hardness, inaccurate individual layer weight control, cross-contamination between the layers, reduced yield, etc. Using a modified tablet press may therefore not be your best approach in producing a quality bi-layer tablet under GMP-conditions. Especially when high production output is required.


Key words:
bilayer tablet, layer separation, insufficient hardness, individual layer weight control