Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
December - 2010 / Volume - 2/Issue - 10
( Total Articles =17 )
December 2010 Issue
Article No 4
December - 2010 / Volume - 2 / Issue - 10 / Article No - 4 / Review Article
FERRO FLUIDS: A PROMISING DRUG CARRIER : A REVIEW
Miss. Sonal A. Patil1*, Mr. H. P. Suryawanshi1,
Mr. Sunil R. Bakliwal1, Dr. Sunil P. Pawar1.
1P. S. G. V. P. Mís College of Pharmacy,
Tal-Shahada, Dist-Nandurbar, 425 409.
Email : Sonalpharma02@gmail.com
Drug targeting is delivery of drug to receptor, organ or to any other specific part of body exclusively. Various non-magnetic micro-carriers like liposomeís, nano-particles, microspheres, micro-particles are successfully utilized for drug targeting but it seemed to have poor specificity and rapidly cleared off by RES (Reticulo-Endothelial System) under normal circumstances. Magnetism plays a very important role in this case. The field of magnetic micro sphere was pioneered in US by Dr. Kenneth Widder and his colleagues in late 1970ís. Magnetic field is believed to be harmless to biological system and adaptable to any part of body. Up to 60% of an injected dose can be deposited and released in controlled manner in selected surface. After administration of that formulated drug place a magnet on body site where one need action. Due to magnetic property drug, get attracted to that site either via enzymatic activity or changes in physiological condition like pH, osmolality, temperature and be taken up by tumour cells. It is a challenging area for future research and holds lots of promises for novel and efficient approach for targeted drug delivery system. This review focuses on drug targeting by Magnetic Microspheres, various magnetic carriers and their characterization.
Key words: magnetic microsphere, magnetic targeted carriers, targeted drug delivery, characterization. .