Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
December - 2010 / Volume - 2/Issue - 10
( Total Articles =17 )
December 2010 Issue
Article No 3
December - 2010 / Volume - 2 / Issue - 10 / Article No - 3 / Research Article
PHARMACOGNOSTICAL STUDIES OF COCCINIA INDICA WIGHT & ARN LEAVES
Niranjan Sutar1*, Ranju Garai1,
Uma Shankar Sharma1,
Narendra Singh1, Saumendu Deb Roy1
1Department of Pharmacy, Sir Madanlal
Group of Institutions,
Etawah-206001, UP, India
The Leaves of Coccinia indica are reported to have good medicinal values in traditional system of medicine. Oral administration of the ethanolic extract of Coccinia indica Wight & Arn leaves (200 mg/kg body weight, CLEt) for 45 days to diabetic rats decreased the concentrations of blood glucose, lipids and fatty acids, viz., palmitic, stearic, and oleic acid whereas linolenic and arachidonic acid and plasma insulin were elevated. The present study highlights the Pharmacognostical as well as phytochemical studies including parameters such as macroscopic, microscopic characters, Physical evaluation and preliminary phytochemical studies of the leaves. These observations will help in the Pharmacognostical identification and standardization of the drug in the crude form and also to distinguish the drug from its adulteration.
Key words: Coccinia indica Wight & Arn, Fresh Kundur leaves, Leaf microscope.