ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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December - 2010 / Volume - 2/Issue - 10
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December 2010
Article No 2
December - 2010 / Volume - 2 / Issue - 10 / Article No -2 / Research Article

FORMULATION AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF AN ANTIMICROBIAL DRUG

Shankar S. J1*,
Gaurav S. Bansal2,
Basavaraj B.V3.

1PES College of Pharmacy, Hanumanthnagar,
Bangalore - 560 050. India
2Dr. H. L. Thimmegowda College of Pharmacy,
Kengal, Channapatana,571502
3M.S.Ramaiah College of Pharmacy, MSRIT Post,
MSR Nagar, Bangalore-560054
Email:shankarsj@rediffmail.com
Shankar S.J.
ABSTRACT

Modified release matrix tablets of ciprofloxacin hydrochloride were prepared with different polymers. The powder mixture was compressed by direct compression method into tablets using rotary tablet compression machine equipped with 13mm tooling of convex surface. Prepared tablets were evaluated for uniformity of content, hardness, thickness, weight variation, friability, in-vitro dissolution studies and stability studies. The in-vitro dissolution study was carried out using USP dissolution test apparatus (paddle type) at100 rpm. The test was carried out at 37 0.5 0 C in 900ml of the N/10 Hcl buffer as the medium for two hours, and pH 7.2 buffer from 2nd hour to 12th hour. The average weight of tablet was observed to be within limits. The thickness, hardness and friability of the prepared tablets were observed to be 5.63-5.72
mm, 5.51-6.28 Kg/cm2 and 0.19 % to 0.45 % respectively. In-vitro dissolution study indicated that matrices containing Chitosan and Guar gum in the ratio 2:1 (F6) showed 93.6 % release after 12 hrs. Whereas for the matrices containing lactose in the percentage of 50 and 75 (F7 & F8) showed 96.15 % and 99.90 % release after 12 hrs respectively. The prepared matrix tablets have not undergone any change either in physical appearance, content or in the dissolution pattern after storage at 45? C & 75 % RH over a period of 6 months.


        

Key words:
Chitosan, Guar gum, Ciprofloxacin Hydrochloride, Direct Compression, Matrix Tablets.