Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
Copyright © 2009 by "International Journal of Pharmaceutica Research and Development" · All Rights reserved · E-Mail: email@example.com
HOW TO PREPARE
Online Since : March 2009
INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
December - 2010 / Volume - 2/Issue - 10
( Total Articles =17 )
December 2010 Issue
Article No 01
December - 2010 / Volume - 2 / Issue - 10 / Article No - 01 / Research Article
CHARACTERIZATION OF FATTY ACID METHYL ESTER CONTENTS OF CORDIA MACLEODII (HOOK.F.& THOMSON) BARK BY GAS CHROMATOGRAPHY - MASS SPECTROMETRY
Pankaj B. Nariya*1, Nayan R. Bhalodia1,
1Research Scholar in phyto chemistry,
I.P.G.T. & R.A.-G.A.U.. Jamnagar
2Head of the Department Pharmaceutical
Laboratory, I.P.G.T. & R.A.-G.A.U.. Jamnagar
3Reader, Department of Dravyaguna, GAU jamnagar, India
The investigation was carried out to determine The chemical composition of the fatty acids methyl esters (FAMEs) bark of Cordia Macleodii were analyzed by gas chromatography-mass spectrometry (GC-MS). GC-MS analysis of Methyl ester of Saponifiable matter led to identification of 12 compounds. This analysis revealed that contains Cordia Macleodii bark mainly Butyric Acid-2, 2 di methyl vinyl ester (19.52%), Butyl Carbinol(14.58%) Gem-Di methyl Cyclopentane (14.34%), Hexadecane (14.01%) , Ciclosano (19.71%) , Heptadeconoic Acid(9.18%).
Key words: Cordia Macleodii, GC-MS analysis.