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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Ocular minitablets (MT) of diclofenac sodium were prepared by single punch compression machine equipped with 4mm flat round tooling specially developed in the lab. Invivo release of drug from ocular MT was determined in rabbit’s eye and invitro release rate of drug was determined at different dissolution volume and rotational speed. Three invitro methods were used for the determination of drugs and their release from various ophthalmic preparations by using Static method, Stirred (paddle) method and Rotating Vial method. . Finding correlation co-efficients and plotting a scatter diagram established invitro-invivo relationship. The Rotating vial method matched best with invivo results Specific hydrodynamic and volume showed high invitro-invivo correlation. The work identified a suitable invitro method of drug release from Ocular minitablets (MT).
Key words: ocular minitablets, controlled release, invitro study, dissolution, IVIVC.
November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 30
November - 2010 / Volume - 2 / Issue - 9 / Article No - 30 / Research Article
EVALUATION OF CONTROLLED RELEASE OPHTHALMIC MINITABLETS PREPARED BY DIRECT COMPRESSION
Dr. Paresh A. Prajapati *1, Sushilkumar S. Poddar2,
R.V. Gaikwad 3, C.N. Galdhar 3,
Vijay Tripathi 3, Madhabhai M. Patel 4
1Department of Pharmaceutics,
K. J. College of Pharmacy, H.N.Gujarat University,
Vadasma, Mehsana, India.
2K. M. Kundnani College of Pharmacy, Colaba,
Mumbai - 400 005.,MH,India
3Veterinary Nuclear Medical Science,
Bombay Veterinary College, Parle, Mumbai.
4Kalol Institute of Pharmacy, Kalol, Gujarat University, Gujarat.,India
Dr. Paresh Prajapati