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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

  The purpose of this investigation was to prepare a gastro retentive drug delivery system of Ketoconazole direct compression technology. HPMC K100LV, HPMC K15M, Ethyl Cellulose and effervescent sodium bicarbonate formed the floating tablet. The prepared tablets exhibited satisfactory physico-chemical characteristics. The floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy and dissolution studies. All the prepared batches showed good in vitro buoyancy. The tablet swelled radically and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for 20-24 h. Final formulation released approximately 89.21% drug in 24 h in vitro, while the floating lag time was not more than 35 Sec and the tablet remained floatable throughout all studies. The tablets with HPMCK15M were found to float for longer duration as compared with formulations containing HPMCK 4 M.
The release of Ketoconazole was found to follow a mixed pattern of Korsmeyer-Peppas, Hixson-Crowell and zero order release models. The optimized formulation was found to be buoyant for 24 h in stomach. The drug release from the tablets was sufficiently sustained and non-Fickian transport of the drug from tablets was confirmed. 



        

Key words:
Ketoconazole, Floating tablets, in vitro buoyancy
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November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 26
November - 2010 / Volume - 2 / Issue - 9 / Article No - 26 / Research Article


PREPARATION AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLETS OF KETOCONAZOLE

Chander Shekar .B1*
, Shireesh Kiran .R1,
Nagendra Babu .B2


1CMR College of Pharmacy, Hyderabad., 2. NIPER,
Hyderabad, AP, India
Email:Shireeshr@gmail.com
ChandraShekar B
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