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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
In the recent days, most of the prevailing diseases and nutritional disorders are treated with natural medicines. Several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or both, resulting poor absorption and poor bioavailability. So, much work has been directed towards the development of new concept in herbal delivery system i.e., “Phytosomes” which are better absorbed, utilized and as a result produce better results than conventional herbal extracts owing to the presence of phosphatidylcholine which likely pushes the phytoconstituent through the intestinal epithelial cell outer membrane, subsequently accessing the bloodstream. Phytosomes have improved pharmacokinetic and pharmacological parameter which in result can advantageously be used in the treatment of the acute and chronic liver disease of toxic metabolic or infective origin or of degenerative nature. It can also be used in anti-inflammatory activity as well as in pharmaceutical and cosmetic compositions.
Key words: Phytosomes, bioavailability, phosphatidylcholine, phytoconstituent, pharmacokinetic.
November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 23
November - 2010 / Volume - 2 / Issue - 9 / Article No - 23 / Review Article
PHYTOSOME: A NOVEL ENTITY IN HERBAL DELIVERY SYSTEM
J. Naga Sowjanya1*, Y.Kiran Kumar1,
Das Saumya1, Pattanayak Dharmajit1.
1Vikas College of B.Pharmacy, Rayinigudem(v),
Suryapet, Andhra Pradesh-508376, India
J. Naga Sowjanaya