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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

Multiple-unit floating beads of clarithromycin were prepared from sodium alginate solution containing hydroxypropylmethylcellulose (K100M) and sunflower oil using the technique of three variables at three levels (33) factorial design and twenty-seven possible batches were prepared. These beads were evaluated for entrapment efficiency, drug loading, buoyancy and in vitro drug release. All formulations showed floating lag time below 2 minutes and showed total floating duration more than 10 hours. The result of in-vitro dissolution studies revealed that the formulation F14 was showing sustained release pattern of clarithromycin. The release rate, entrapment efficiency, drug loading and buoyancy was greater with formulation containing 2 percent sodium alginate solution and 5 percent calcium chloride solution along with 5 ml sunflower oil. 


        

Key words:
Floating alginate beads; emulsion gelation; clarithromycin; controlled release.
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November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
P.K. Nimse
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Article No 21
November - 2010 / Volume - 2 / Issue - 9 / Article No - 21 / Research Article


PREPARATION AND EVALUATION OF MULTIPLE-UNIT FLOATING DRUG DELIVERY SYSTEM OF CLARITHROMYCIN

Pradeep Kisan Nimase*1
, Vidyasagar Gali2,
Prashant Jalindar Ghule.1


1Mula Education Sosiety’s College of Pharmacy,
Sonai, Tal: Newasa, Dist: Ahmednagar
2Virayatan Institute of Pharmacy, Kutch-Bhuj, Gujarat
Email:pradeepnimase@rediffmail.com