Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
Welcome to "International Journal of Pharmaceutical Research and Development"  i.e. "IJPRD"
HOW TO PREPARE   
YOUR PAPER
What's New | Feedback | Copyright and Disclaimer
Online Since : March 2009
Only 15 Articles will be Published in Each Issues
TODAY IS
Abstract Content
Model Abstract
Summary Content
Model Summary

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
- : BACK TO CURRENT ISSUE OF JOURNAL :-
((( PREVIOUS ARTICLE
NEXT ARTICLE )))
ABSTRACT

  Hypertension is very dangerous problem; it may occur any time to elder patients, so drugs are available for all the times and administered by patients are very easy mode. Normally all drugs are administered by oral route with water or some other liquid vehicles. At the time of emergency (for hypertension patients) water may get or not. So, to overcome these problems, tablets are to be developed and administered with out need of water. The purpose of this research was to develop oral disintegrating tablets (ODT) of low bitter hypertensive drugs like amlodipine besylate using taste enhancers as a taste masking agents. ODT of amlodipine besylate were prepared using different superdisintegrants by direct compression method.  Mannitol was used as a diluent and sodium lauryl sulphate was used as a wetting (surfactant) agent. Aspartame and Acesulfame Potassium were used for unpleasant taste masked from the amlodipine besylate by cosifting and serial of blending with other excipients.  The mixed final blend was then compressed into tablets. The formulations were evaluated for weight variation, hardness, friability, wetting time, disintegrating time, dissolution, taste evaluation study and in vitro dissolution. All the formulation showed low weight variation with different disintegration time and rapid in vitro dissolution. The results revealed that the tablets containing taste enhancers had a good palatability for the patients. The optimized formulation showed good taste masking, less disintegration time (<30seconds) and release profile with maximum drug being released at all time intervals. The present study demonstrated potentials for rapid disintegration in oral cavity with out water, improved taste masking and patient compliance.


        

Key words:
Amlodipine besylate, Diluents, Direct compression, Oral disintegrating tablets (ODTs), Superdisintegrants and Taste enhancers.
Past Issues

March 2009

April 2009

May 2009

June 2009

July 2009

August 2009

September 2009

October 2009

November 2009

December 2009

January 2010

February 2010

March 2010

April 2010

May 2010

June 2010


July 2010

August 10

September 10
November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 19
November - 2010 / Volume - 2 / Issue - 9 / Article No - 19 / Research Article

DEVELOPMENT AND CHARACTERIZATION OF TASTE MASKED COMPRESSED ODT FORMULATION OF LOW BITTER DRUG

Venkata Ramana Reddy S*1,

Sathyanarayana Dondeti1, Manavalan R1,
Sreekanth J2

1Department of Pharmacy, Annamalai University,
Annamalai Nagar, Tamilnadu, India.
2Natco pharma ltd., R&D center, Kothur,
Hyderabd, India.
Email:svrreddy6@gmail.com
V. Ramana Reddy
[ VIEW FULL ARTICLE ] [PDF VIEW ]