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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

  The antipyretic  effect  of  the  methanolic  extract  of  leaves  of  Quisqualis  indica  Linn. against  brewer yeast induced pyrexia model in wistar rats of both sexes was investigated.  Pyrexia was  induced by subcutaneously injecting 20% w/v brewer's yeast suspension (10 ml/kg) into the animals' dorsum region. Twelve hours  after  the  injection, the rectal temperature of each rat was measured .The  temperature was  measured  at 0, 1, 2, 3 and 4hr after drug administration. Aspirin (150 mg/kg p. o.) was used as standard drug. The group received methanolic extract 100mg/kg and 200mg/kg showed significant decrease in rectal temperature from 38.40± 0.075 to 37.44 ± 0.0638 and 38.99 ± 0.140 to 37.49 ± 0.038 respectively as  compared with  the  group  received  standard drug . All the values are expressed as mean   ± standard  deviation   and   analyzed  for  ANOVA  and  post  hoc Dunnet’s t-test. Differences between groups were considered significant at P < 0.01 levels. . The statistically processed results support the conclusion, that the methanolic extract of Quisqualis indica (Linn.) leaves (100mg/kg and 200mg/kg) possesses dose  dependent, significant  antipyretic  activity   against   brewer  yeast  induced  pyrexia.



        

Key words:
Quisqualis indica , Antipyretic ,Subcutaneous , Dunnet’ s t -test,  Anova ,Aspirin.

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November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 18
November - 2010 / Volume - 2 / Issue - 9 / Article No - 18 / Research Article

ANTIPYRETIC ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF QUISQUALIS INDICA LINN.

Nitu Singh
1, Pankaj Khatri1, Dr.K.C.Samantha2,
Reena Damor1

1Deaprtment of Pharmacognosy ,
Suresh Gyan Vihar University; Jaipur,RJ, India
2Deaprtment of Biotechnology,
Suresh Gyan Vihar University; JaipurRJ, India
Email:nanhushagun@gmail.com
Nitu Singh
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