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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
The antipyretic effect of the methanolic extract of leaves of Quisqualis indica Linn. against brewer yeast induced pyrexia model in wistar rats of both sexes was investigated. Pyrexia was induced by subcutaneously injecting 20% w/v brewer's yeast suspension (10 ml/kg) into the animals' dorsum region. Twelve hours after the injection, the rectal temperature of each rat was measured .The temperature was measured at 0, 1, 2, 3 and 4hr after drug administration. Aspirin (150 mg/kg p. o.) was used as standard drug. The group received methanolic extract 100mg/kg and 200mg/kg showed significant decrease in rectal temperature from 38.40± 0.075 to 37.44 ± 0.0638 and 38.99 ± 0.140 to 37.49 ± 0.038 respectively as compared with the group received standard drug . All the values are expressed as mean ± standard deviation and analyzed for ANOVA and post hoc Dunnet’s t-test. Differences between groups were considered significant at P < 0.01 levels. . The statistically processed results support the conclusion, that the methanolic extract of Quisqualis indica (Linn.) leaves (100mg/kg and 200mg/kg) possesses dose dependent, significant antipyretic activity against brewer yeast induced pyrexia.
Key words: Quisqualis indica , Antipyretic ,Subcutaneous , Dunnet’ s t -test, Anova ,Aspirin.
November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 18
November - 2010 / Volume - 2 / Issue - 9 / Article No - 18 / Research Article
ANTIPYRETIC ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF QUISQUALIS INDICA LINN.
Nitu Singh1, Pankaj Khatri1, Dr.K.C.Samantha2,
1Deaprtment of Pharmacognosy ,
Suresh Gyan Vihar University; Jaipur,RJ, India
2Deaprtment of Biotechnology,
Suresh Gyan Vihar University; JaipurRJ, India