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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

To investigate the absorption and the inhibition of glucose by the aqueous seed extracts of Eugenia jambolana. The small intestine of all animals were removed, washed with 0.9% (w/v) normal saline and intestinal segments were everted the empty sac was filled with 0.5 ml of the KHB buffer and placed in a stoppered conical flask with 5 ml of the buffer with varying concentration of glucose and 3.62 mf of To investigate the absorption and the inhibition of glucose by the aqueous seed extracts of Eugenia jambolana. The small intestine of all animals were removed, washed with 0.9% (w/v) normal saline and intestinal segments were everted the empty sac was filled with 0.5 ml of the KHB buffer and placed in a stoppered conical flask with 5 ml of the buffer with varying concentration of glucose and 3.62 mf of Eugenia jambolana seed extract.  The conical flask was placed in metabolic shaker at a frequency of 100-110 shakes/min. The incubation medium was bubbled for 1 min with a mixture of 95% O2 and 5% CO2. After 30 min of incubation medium the sacs were removed and the serosal fluid was drained into a test tube. Glucose in the mucosal and the serosal compartment was measured.  Incubation of the Eugenia jambolana seed extracts with rat everted gut sacs resulted in the inhibition of the transport of glucose across the membrane. Based on the data obtained in this study, we can propose that aqueous seed extract of Eugenia jambolana may possess hypoglycemic properties that inhibit the glucose transport at the site of intestinal brush border membrane.

        

Key words:
Hypoglycemic, Eugenia jambolana, Aqueous extracts.
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November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 16
November - 2010 / Volume - 2 / Issue - 9 / Article No - 16 / Research Article

EUGENIA JAMBOLANA SEED EXTRACT INHIBIT UPTAKE OF                                             GLUCOSE ACROSS RAT EVERTED GUT SACS IN VITRO

E David1*,S. Viviyan Therasa1,
J. Hemachandran2,
EK. Elumalai1,T.Thirumalai1


1Department of Zoology, Nano-Physiology wing,
Voorhees College, Vellore-632001, (T.N). India.
2Department of physiology, Asella Medical College,
Adama University,  Ethiopia, North Africa.
Email:ernestdavid2009@gmail.com     
E David
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