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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

The current study was undertaken to evaluate anti-inflammatory activity of alcoholic extract of seeds of trigonella-foenum-graceum (Fenugreek) on Wister strain rat. Seeds were collected, air dried, reduced to no: 36 powder and extracted with petroleum ether at 60-80C followed by extracted with 50% aqueous methyl alcohol. The acute anti-inflammatory activity of trigonella-foenum-graceum (100mg & 200mg/kg b.w) was measured plethysmographically using carrageenan as inflammatory agent, keeping indomethacin (10mg/kg b.w) as reference standard. Trigonella-foenum-graceum (100mg/kg b.w) had shown significant difference with control (P<0.05) at 3rd, 4th, 6th hr. Trigonella-foenum-graceum (200mg/kg b.w) and Indomethacin (10mg/kg b.w) showed significant anti-inflammatory effect (P<0.025) up to 4 hour. The study indicated that alcoholic extract of Trigonella-foneum-graceum exhibited anti-inflammatory effect on carrageenan induced paw oedema in rats at dosage of both at 100mg & 200mg/kg b.w. This low dose of fenugreek was more significant than Indomethacin. Therefore we can conclude that the alcoholic and petroleum ether extracts of fenugreek seeds can be used safely (within the extremes of our study) as anti inflammatory agent.

        

Key words:
Trigonella foeum graceum , Fenugreek, anti-inflammatory agent, carrageenan, paw oedema.

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November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 12
November - 2010 / Volume - 2 / Issue - 9 / Article No - 10 / Research Article

A STUDY OF ANTI-INFLAMMATORY ACTIVITY OF ALCOHOLIC EXTRACT OF SEEDS OF TRIGONELLA FOENUM GRACEUM (FENUGREEK) ON WISTER STRAIN RAT

Datta Debranjan1*
, Shanbagh Tara2


1Department of Pharmacology, Sikkim Manipal
Institute of Medical Sciences,
5th mile, Tadong, Gangtok, Sikkim, India
2Department of Pharmacology, Kasturba
Medical College, Manipal, Karnataka, India
Email:debranjandatta@gmail.com
Datta Debranjan
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