Copyright © 2009  by "International Journal of Pharmaceutica Research and Development"  ·  All Rights reserved  ·  E-Mail: info@ijprd.com
Welcome to "International Journal of Pharmaceutical Research and Development"  i.e. "IJPRD"
HOW TO PREPARE   
YOUR PAPER
What's New | Feedback | Copyright and Disclaimer
Online Since : March 2009
Only 15 Articles will be Published in Each Issues
TODAY IS
Abstract Content
Model Abstract
Summary Content
Model Summary

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
- : BACK TO CURRENT ISSUE OF JOURNAL :-
((( PREVIOUS ARTICLE
NEXT ARTICLE )))
ABSTRACT

Acetaminophen (APAP) is a commonly used analgesic and antipyretic agent which, in high doses, causes liver and kidney necrosis in man and animals. Herbal medicines have recently attracted much attention as alternative medicines for treating or preventing life style related disorders of nephrotoxicity but relatively very little knowledge is available about their mode of action. Anthoxanthum odoratum Linn (Sweet Vernal Grass), family “Poaceae” is especially provocative  to hay fever and hay asthma, a medicinal tincture from it is sniffed well into the nose and throat for immediate relief from congestion. It has been reported to be biologically active for growth inhibitor and effective for nephrotoxic activity.

The aim of the present study was to investigate the nephrotoxic and antioxidant activities of the ethanol extract of Anthoxanthum odoratum at two doses level of 250mg/kg & 500 mg/kg B/W on acetaminophen- induced toxicity in rats. Biochemical studies shows that increased the levels of body weight, serum urea, hemoglobin (Hb), total leucocyte count  (TLC), creatinine (CR), packed cell volume (PCV), differential leucocyte count (DLC) and mean corpuscular volume (MCV) along with reduction in the levels of neutrophil, mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin  (MCH),   granulocytes, uric acid, platelet concentration (PLC) in acetaminophen- induced groups. These values are retrieved significantly with treatment of  Anthoxanthum odoratum extract at two different doses. The antioxidant study reveals that the levels of renal superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione peroxidase (GPx) in the APAP treated animals are increased significantly along with decreased malonodialdehyde (MDA) content in ethanol extract of Anthoxanthum odoratum treated groups. In conclusion, these data suggest that the ethanol extract of Anthoxanthum odoratum can prevent renal damage from APAP-induced nephro toxicity in rats and this is likely mediated through its antioxidant activities.


Key words:
Acetaminophen, antipyretic agent, Anthoxanthum odoratum antioxidant activities
Past Issues

March 2009

April 2009

May 2009

June 2009

July 2009

August 2009

September 2009

October 2009

November 2009

December 2009

January 2010

February 2010

March 2010

April 2010

May 2010

June 2010


July 2010

August 10

September 10
November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 11
November - 2010 / Volume - 2 / Issue - 9 / Article No - 10 / Review Article

EVALUATION OF NEPHROPROTECTIVE AND ANTIOXIDANT ACTIVITY OF
ANTHOXANTHUM ODORATUM ON ACETAMINOPHEN INDUCED TOXICITY IN RAT


V.L.Dheeraj*,
A. Srikar Reddy, S. Subramanyam,
S.Raja


1 Bharat Institute of Technology, Ibrahimpatnam,
Hyderabad-501510, Andhra Pradesh -India
Email:vldheeraj@yahoo.com
V.L. Dheeraj
[ VIEW FULL ARTICLE ] [PDF VIEW ]