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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

A simple, rapid and selective HPLC method has been developed for quantization of Amlodipine Besylate and Metoprolol succinate from bulk drug and pharmaceutical formulations using a mobile phase consisting mixture of 0.02 M phosphate buffer solution
and Acetonitrile as 80:20 at the flow rate of 1 mL/min. An Inertsil ODS-CV column was used as stationary phase. The retention time of Amlodipine Besylate and Metoprolol succinate were 3.92 and 10.43 respectively. Linearity was observed in the concentration range of 2.5 to 15 g/ml for Amlodipine Besylate and 25 to 150 g/ml for Metoprolol succinate, with good linearity response greater than 0.999. Percent recoveries obtained for Amlodipine Besylate and Metoprolol succinate were 100.03 and 100.48% respectively. The proposed method is precise, accurate, selective and rapid for the simultaneous determination of Levofloxacin hemihydrate and Orinadozole.


Key words:
Amlodipine Besylate; Metoprolol succinate; HPLC Method
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November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 10
November - 2010 / Volume - 2 / Issue - 9 / Article No - 10 / Review Article

RP-HPLC METHOD OF SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND METOPROLOL IN COMBINED DOSAGE FORM


CH.M.M.Prasada Rao 1*
, S.A.Rahaman 2,
Y.Ragjendra Prasad 3, P. Gangi Reddy 4


1Department of chemistry, ST Anns college of Pharmacy,
Nayunipally, Vetapalem-523187, A.P, India.
2
Nirmala College of pharmacy, Atmakur,
Mangalagiri, Guntur (DT), A.P., India,
3Univeristy college of Pharmaceutical Sciences,
Andhra University, Vishakhapatnam-530003, A.P., India.
4Depatment of Pharmacy, Annamalai University, Chidambaram, T.N, India
Email:chennuprasad@gmail.com
MM Prasad
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