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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

  This work is concerned with application of simple, accurate, precise and highly selective reverse phase high performance liquid chromatographic (RP-HPLC) method for simultaneous estimation of simvastatin and ezetimibe in combined dosage form. Chromatographic separation was achieved isocratically phenomenax C18 column (250 ? 4.6 mm i.d.) with a mobile phase composed of 75:20:5 of acetonitrile:methanol:orthophosphoric acid (0.1%) % v/v/v at flow rate of 1 ml/min. Detection is carried out using a UV-vis detector at 238 nm. The retention time of simvastatin and ezetimibe was found to be 3.701 min and 5.975 min. respectively. The method was found to be linear in the range of 50-175 g/ml with mean recovery of 99.78% for simvastatin and 98.81% for ezetimibe. The correlation coefficients for all components are close to 1. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed method was successfully applied for simultaneous determination of simvastatin and ezetimibe in routine analysis.


        

Key words:
reverse phase high performance liquid chromatographic (RP-HPLC), isocratically phenomenax, ezetimibe, simvastatin and ezetimibe, routine analysis.
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November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 8
November - 2010 / Volume - 2 / Issue - 9 /Article No - 08/ Review Article

SIMULTANEOUS ESTIMATION OF SIMVASTATIN AND EZETIMIBE IN PHARMACEUTICAL TABLET DOSAGE FORMS BY RP-HPLC



Mujeeb ur Rahman*1, Gazala Parveen1, N.K.Nyola1,
Shahroz Khan2,Sushma Talegaonkar2,
M. Shahar yar2 and R.K.Khar2


1Alwar Pharmacy College, Alwar, Rajasthan ,India
2Jamia Hamdard ,New Delhi , India .
Email: mujeebhamdard@gmail.com
Mujeeb Rahman
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