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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

    Indomethacin, an anti-inflammatory drug, exhibits poor water solubility and flow properties. Spherical agglomerates were prepared by solvent change method. Solvent composition for spherical agglomeration was determined by constructing ternary diagram. Crystallization medium used for spherical agglomerates of indomethacin consisted of N,N-dimethylformamide (good solvent); water (poor solvent); chloroform (bridging liquid) in the ratio of 25:62.5:12.5, respectively. Spherical agglomerates were characterized by differential scanning calorimetry, Infrared spectroscopy, X-ray diffractometry and scanning electron microscopy. Gas phase chromatography was carried to estimate the residual dimethylformamide and chloroform. Micromeritic and dissolution behavior studies were carried out. Process variables such as amount of bridging liquid, stirring time and duration of stirring were optimized. Dissolution profile of the spherical agglomerates was compared with commercial sample and recrystallized sample. Spherical agglomerates exhibited decreased crystallinity and improved micromeritic properties. The dissolution of the spherical agglomerates was improved compared with commercial sample. 


Key words:
spherical agglomerates, indomethacin, dissolution, crystallinity.

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November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 5
November - 2010 / Volume - 2 / Issue - 9 / Article No - 5 / Research Article

PHERICAL AGGLOMERATION OF INDOMETHACIN BY SOLVENT CHANGE METHOD

Mudit Dixit*1,
P. K. Kulkarni1, P. Subhash Chandra Bose1 

1Department of Pharmaceutics,
J. S. S. College of Pharmacy,
S. S. Nagar,Banimantap, Mysore-570015
Karnataka, India.
Email: muditdixit911@yahoo.com
Mudit Dixit
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