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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

Juveniles of the African cat fish Clarias gariepinus (Teugels) of standard length 16.50 00.25 cm and weight 14.75 1.25g were exposed to methanol extract of Tephrosia vogelii F. (Hook), ten each in a glass aquaria of nominal concentrations 0, 2.40, 2.45, 2.46, 2.50, 2.55 and 2.56 mgl-l in three replications for 96hours to determine the acute toxicity using flow through bioassay. Symptoms of toxicosis such as agitated swimming, loss of balance, ventral resting position, and death were observed. Percentage mortality was recorded every 24hours and converted to probit kill table value. Opercular ventilation was higher than the control at P<0.05. A dose dependant significant increase was observed and the beats decreased with time at P<0.05. The lethal concentration at 96 hours (LC50) was determined using probit kill analysis and was found to be 2.47mgl-l. The use of T. vogelii as a means of catching fish should be discouraged considering the low LC50 of a very hardy fish C. gariepinus. This signifies that non target organisms will be affected in the ecosystem.

        

Key words:
Toxicity, Mortality, lethal concentration, Clarias gariepinus and Tephrosia vogelii
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November - 2010 / Volume - 2/Issue - 9
( Total Articles =31 )
November 2010 Issue
Article No 01
November - 2010 / Volume - 2 / Issue - 9 / Article No - 01 / Research Article

TOXICITY OF METHANOL EXTRACT OF TEPHROSIA VOGELII, F. (HOOK) TO THE JUVELINES OF AFRICAN CAT FISH CLARIAS GARIEPINUS, (TEUGELS)

J.I. Usman1*,
  J. Auta2,  A.K.  Adamu2 ,
P.I.Bolorondro3

1Department of Science Laboratory Technology
Federal Polytechnic Nasarawa. Nigeria.
2Department of Biological Sciences
Ahmadu Bello University Zaria.Nigeria.
3
Department of livestock& fisheries NAREC
Ahmadu Bello University Zaria. Nigeria.
Email:onairujibril@yahoo.com
J.I. Usman