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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

   Ketorolac Tromethamine is having analgesic and NSAID category, the general side effect are related to gastrointestinal tract. Reduction of side effects while prolonging its action by using controlled release of oral dosage forms is highly desirable. In the present study direct compression method is used for the preparation of fabricated batches and EudragitL100 is used as coating polymer for enteric coating. In vitro release profiles of batches F1-F4 shows that Ketorolac Tromethamine  in drug :polymer ratio with Guar gum, Xanthan Gum, Ethyl cellulose and Sodium alginate give 79.32%, 91.52%, 88.35% and 92.19% drug release respectively in 12 hours. In vitro release profile of batches F5-F8 shows that Ketorolac Tromethamine in ratio 1:4 with Guar gum, Xanthan Gum, Ethyl cellulose and Sodium alginate gives release of 85.21%, 95.52%, 93.50%, 97.24% respectively in 12 hours. In vitro release profile of batches F9-F12 shows that Ketorolac Tromethamine in ratio 1:3 with Guar gum, Xanthan Gum, Ethyl cellulose and Sodium alginate gives release of 89.50%, 98.25%, 95.22%, 100.27% respectively in 12 hours. All the batches showed no drug release in first two hours in hydrochloric buffer of pH 1.2 and then showed higher increase in phosphate buffer of pH 6.0 up to 12 hours. All these batches follow near zero order kinetic. This indicates that the Guar Gum, Xanthan Gum and Ethyl cellulose and Sodium alginate at minimum concentration is not only able to sustain but also control the drug release.


        

Key words:
Ketorolac Tromethamine, direct compression, enteric coating, Control release, 
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October - 2010 / Volume - 2/Issue - 8
( Total Articles =20 )
October 2010 Issue
Article No 20
October - 2010 / Volume - 2 / Issue - 8 / Article No - 20 / Research Article


FORMULATION AND DEVELOPMENT OF ENTERIC COATED DOSAGE FORM USING KETOROLAC TROMETHAMINE

  Rupesh S. Kamble*, Archana D. Kajale,
Keshao P. Giradkar
B. V. Bakade, M. A. Channawar, A. V.  Chandewar


1Department of Pharmaceutics
P. Wadhwani College of Pharmacy,
Yavatmal - 445001.
Email: rskamble42@gmail.com


Rupesh Kamble