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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

  
In this study, a series of novel N-(5-(2-arylidenehydrazinecarbonyl) benzoxazol-2-yl) -2-(dialkylamino) acetamide derivatives have been synthesized and their structures were confirmed by IR, 1H NMR, and mass spectral data. These compounds were prepared by reacting2-(dialkylamino)-N-(5-(hydrazinecarbonyl) benzoxazol-2-yl acetamides, which were obtained by using Methyl-2-(2-(dialkylamino)acetamido)benzoxazole-5-carboxylates with Hydrazine hydrate (99%) All synthesized compounds VIIIa-h were tested by using the method of twofold serial dilution technique for in vitro activities against certain strains of Gram-positive, Gram-negative bacteria as well as the yeasts Candida albicans, Candida krusei, and Candida glabrata in comparison with standard drugs. Microbiological results showed that the newly synthesized compounds possessed a broad spectrum of activity, showing MIC values of 3.12-50 g/mL against the Candida species.



        

Key words:
Benzoxazoles; Antibacterial activity; Antifungal activity; Gram-Positive; Gram-negative
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October - 2010 / Volume - 2/Issue - 8
( Total Articles =20 )
October 2010 Issue
Article No 15
October - 2010 / Volume - 2 / Issue - 8 /Article No - 10 / Research Article

SYNTHESIS AND
ANTIMICROBIAL ACTIVITY OF SOME N-(5-(2-ARYLIDENEHYDRAZINECARBONYL) BENZOXAZOL-2-YL) -2-(DIALKYLAMINO) ACETAMIDE DERIVATIVES

Srinivas Ampati*1
, Vidyasagar Jenugu,
Raju Jukanti , Sarangapani Manda

1Medicinal Chemistry Research Laboratories,
University College of Pharmaceutical Sciences,
Kakatiya University,
Warangal, 506 009, Andhra Pradesh, India.
Email:ampatykips@gmail.com
Srinivas Ampati