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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

        A High Performance Liquid Chromatographic method has been developed for the analysis of Lumefantrine in the solid dosage form. The mobile phase consisting of acetonitrile and methanol in ratio the of (50:50 % v/v) was delivered at the flow rate of 2.0 ml/min and diode array detection was carried out at 235 nm. The separation was achieved using C18 reverse-phase column (250 X 4.6 mm I.D., particle size 5m). The method was linear over the concentration range of 50 - 150 g/ml for Lumefantrine. The analytical recovery obtained was 99.76%.The validation of method was carried out as per ICH guidelines. The described HPLC method was successfully employed for the analysis of pharmaceutical formulations containing Lumefantrine and can be employed for bioequivalence study in future for the same formulations.





        

Key words:
RP-HPLC, Lumefantrine, Validation.
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October - 2010 / Volume - 2/Issue - 8
( Total Articles =20 )
October 2010 Issue
Article No 14
October - 2010 / Volume - 2 / Issue - 8 / Article No - 14 / Research Article

METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF
LUMEFANTRINE IN SOLD DOSAGE FORM BY RP-HPLC




                        Rajasekaran Prasanna1*, Devarajan Saravanan2,
Jagannathan Padmavathy2, Kandasamy Boopathi3

               


1Quest Life Sciences Pvt. Ltd, SDFIII, 3rdfloor, MEPZ, Tambaram, Chennai - 600 045.
2Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh, India- 524 346.
  3Srinivasa Pharmaceutical Institute and Centre for Research, Burugupally village,Vikarabad, Rangareddy district, Andhra Pradesh, India- 501 101.
Email: rajasekaran.prasanna759@gmail.com
Rajsekaran Prasanna