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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

  The main purpose of this work was to develop a microemulsion formulation for enhancing the bioavailability of isotretinoin. A Captex-355®-based microemulsion formulation with Cremophor EL® as surfactant and ethanol as cosurfactant was developed for oral delivery of isotretinoin. Phase behavior and solubilization capacity of the microemulsion system were characterized, and in vitro oral absorption of isotretinoin from the microemulsion was investigated. A single isotropic region, which was considered to be a bicontinuous microemulsion, was found in the pseudoternary phase diagrams developed at various Cremophor EL: Ethanol: Captex-355 ratios. With the increase of Cremophor EL concentration, the microemulsion region area and the amount of water and Captex-355 solubilized into the microemulsion system increased; however, the increase of ethanol percentage produced opposite effects. The microemulsion system was also investigated in terms of other characteristics, such as interfacial tension, viscosity, pH, refractive index, in vitro diffusion and droplet size analysis. Isotretinoin, a poorly soluble drug, displayed high solubility in a microemulsion formulation using Captex-355 (5%), Cremophor EL (28%), Ethanol (7%), and water (60%). The in vitro diffusion study revealed an increase of bioavailability (38.56 times) after in vitro drug diffusion analysis of the microemulsion formulation as compared with the commercially available soft gelatin capsules.





        

Key words:
Microemulsion, nonionic surfactant, conductivity, interfacial tension, droplet size
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October - 2010 / Volume - 2/Issue - 8
( Total Articles =20 )
October 2010 Issue
Article No 13
October - 2010 / Volume - 2 / Issue - 8 / Article No - 10 / Research Article

DESIGN AND DEVELOPMENT OF MICROEMULSION DRUG DELIVERY SYSTEM OF ISOTRETINOIN FOR IMPROVEMENT OF BIOAVAILABILITY

Kashyap Nagariya*1
,Manikandan R.2,
Sebastian B.3, and Naruka P.S.4


1Formulation Res. and Dev., Kusum Healthcare
Pvt. Ltd., Bhiwadi-301019 (Raj.)
2Product Development and Research,
Dr. Reddy Research Laboratories, Hyderabad (AP)
3Product Development and Research,
Ranbaxy Research Laboratories, Gurgaon (HR)
4Department of Pharmaceutics, Bhupal Nobles’ College of Pharmacy, Udaipur (Raj.)
Email:nagariya.kashyap@gmail.com
Kashyap Nagariya