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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT
  
    Two simple and sensitive spectrophotometric methods in UV and visible region were developed for the estimation of Citicoline in pharmaceutical dosage forms. Method A is showing absorption maximum at 272 nm in distilled water.  Method B is based on the reaction of 3-methyl-2-benzothiazolin-2-one hydrazone (MBTH) with Citicoline in presence of ferric chloride solution to yield a yellow orange colour. This colour has a characteristic light absorption in the visible region with absorption maximum at 625 nm. These methods obey Beer's law in the concentration range of 10-70 g/ml and 50-250 g/ml respectively. The proposed method is precise, accurate and reproducible. It can be extended to the analysis of Citicoline in tablet formulations.


        

Key words:
Citicoline, MBTH, UV Spectrophotometry.
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October - 2010 / Volume - 2/Issue - 8
( Total Articles =20 )
October 2010 Issue
Article No 5
October - 2010 / Volume - 2 / Issue - 8 / Article No - 5 / Research Article

NEW SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF CITICOLINE IN PHARMAEUTICAL FORMULATIONS

Malipatil S.M1*
, Patil S.K1, Deepti.M1,
Kishwar Jahan1

1Department of Pharmaceutical Analysis,
H.K.E.S College of pharmacy,
Gulbarga-585 105(K.S.) INDIA
Email: shivareddy51@rediffmail.com
Malipatil S. M.