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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

  This study was designed to study simple method for the separation of husk from the seeds of Trigonella-foenum graecum (fenugreek). The entire seeds were subjected to size reduction followed by successive extractions with chlorinated hydrocarbons to separate the husk from the 'core and oily portion' to yield about 40% w/w of the husk. The dried husk was further powdered. Various physicochemical parameters including swelling index, particle size distribution and flow properties were studied. Use of fenugreek husk as a binding in tablets was investigated. Ibuprofen was used as model drug for optimizing the binding properties of husk in tablets using fenugreek husk dispersion, comparing the results against starch paste. Friability, hardness, disintegration, weight variation and dissolution were the parameters of comparative studies. Fenugreek husk dispersion was found to be superior over starch paste, on the basis of the selected parameters. The maximum concentration required of the husk as a binding agent was 4 -6% of the dosage form, which is relatively low as compared to starch.


        

Key words:
Fenugreek husk, swelling index, binding agent
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October - 2010 / Volume - 2/Issue - 8
( Total Articles =20 )
October 2010 Issue
Article No 3
October - 2010 / Volume - 2 / Issue - 8 / Article No - 3 / Research Article

EVALUATION OF FENUGREEK SEED HUSK AS TABLET BINDER

Manoj M Nitalikar1*, Rama A. Patil1, Swati D. Dhole1,
Dinesh M. Sakarkar2

1Department of Pharmaceutics, SVERIís
College of Pharmacy, Pandharpur,
Dist. Solapur,Maharashtra (India)
2Department of Pharmaceutics, Sudhakarrao Naik
Institute of Pharmacy,Pusad,
Dist. Yavatmal, Maharashtra (India)
E-mail: manojnitalikar@lycos.com
Manoj Nitalikar