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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

   The continual search for antimicrobial agents from plants has become necessary due to the prevailing development of microbial resistance to the existing ones. The antimicrobial analysis of the ethanolic and aqueous extracts of the stem bark, root and leaf of Rauvolfia caffra was performed against Pseudomonas aeruginosa NCTC 6750, Bacillus subtilis NCTC 8236, Staphylococcus aureus NCTC 8530 and Escherichia coli NCTC 10418.  The antimicrobial activities of the extracts of Rauvolfia caffra were determined using agar dilution and agar diffusion methods. The zones of inhibition of the ethanolic extracts of the stem bark, root and leaf ranged from 11.0mm - 30.0mm while the aqueous stem bark, root and leaf extracts ranged from 11.0mm - 20.0mm. The Minimum Inhibitory Concentrations (M.I.C.) ranged from 2.5 - 20.0mg/ml and the Minimum Bactericidal Concentrations (M.B.C.) ranged from 5.0 - 20.0mg/ml depending on the organism and the type of solvent used for the extraction. There were significant (P<0.05) differences in the antibacterial activities of the stem extracts and the other extracts against E. coli NCTC 10418 during the investigation. The phytochemical screening of the stem bark, root and leaf of the plant, which was carried out using standard protocols revealed the presence of tannin, alkaloid, glycoside, saponin, flavonoids, carbohydrate and anthracene. The study has shown that the ethanolic and aqueous extracts of the stem bark, root and leaf of Rauvolfia caffra contain some antibacterial properties as claimed by herbal practitioners.     



        

Key words:
Rauvolfia caffra, ethanolic extract, aqueous extract.
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October - 2010 / Volume - 2/Issue - 8
( Total Articles =20 )
October 2010 Issue
Article No 01
October - 2010 / Volume - 2 / Issue - 8 / Article No - 01 / Research Article

PRELIMINARY IN-VITRO ANTIBACTERIAL ACTIVITIES OF ETHANOLIC AND AQUEOUS EXTRACTS OF RAUVOLIFIA CAFFRA.


Adeshina Gbonjubola O.1*
, Noma Samuel T.1,
Onaolapo Josiah A.1, Ehinmidu Joseph O.1

1Department of Pharmaceutics and
Pharmaceutical Microbiology,
Ahmadu Bello University, Zaria, Nigeria.
Email:dotunkele@yahoo.com
Adeshina Gbonjubola