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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFIXIME AND SATRANIDAZOLE

Manjunatha.K*1,
Chandrasekhar Javali1, M.D.Karvekar1, Somashekar.P.L1

1
Department of Pharmaceutical Chemistry,
Government College of Pharmacy,
Subbaiah Circle, Bengaluru-560027, India
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
An RP-HPLC method was developed and validated for the simultaneous determination of Cefixime Trihydrate and Satranidazole. The chromatographic system was equipped with Phenomenex C18 column and PDA detector set at 254 nm, in conjunction with a mobile phase of Phosphate Buffer, Acetonitrile and Methanol in the ratio of 50:30:20 (pH 5), at a flow rate of 1.0ml/min. The retention time of Cefixime Trihydrate and Satranidazole were found to be 2.30 0.05 and 4.2 0.05 minutes respectively. Linearity was observed in the concentration range of 1-10g/ml for Cefixime Trihydrate and Satranidazole, with good linearity response of 0.998 and 0.998 respectively.  Percentage recoveries obtained for Cefixime Trihydrate and Satranidazole were 98-100% and 99-102% respectively. The proposed method is precise, accurate, selective and rapid for the simultaneous determination of Cefixime Trihydrate and Satranidazole.
This method can be used to estimate either of these drugs individually when present separately in formulation or in combination.

KEYWORDS : Cefixime Trihydrateand Satranidazole; HPLC Method.


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