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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
EVALUATION AND IMPORTANCE OF AMOUNT OF NEUROSTEROIDS IN NICOTINE ADDICTION BY SIMULTANEOUS QUANTIFICATION OF NEUROSTEROIDS IN MICE BRAIN DURING NICOTINIC SENSITIZATION WITH HPLC

Monappa R. Sutar1*,
Dr. C. R. Tenpe2

1
Institute of Pharmaceutical Education and Research,
Borgaon Meghe, Wardha, MH, India
2Head Department of Pharmacology, Institute of pharmaceutical &
Education Research, Borgaon Meghe,
Wardha, Maharashtra State, India - 442 001.
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
Nicotine is one of the major addictive substances consumed by people in the India and world. In order to access the effect of nicotine on content of neurosteroids in brain was studied. The naive mice were used for the nicotinic sensitization with the prior permission of ethical committee. The model for the nicotinic sensitization study used was actophotometer for the measurement of locomotor activity by nicotinic sensitization. Estimation of the brain neurosteroids in mice brain during the developmental phases, withdrawal phase and sensitized phase of nicotinic sensitization were done with the validated high performance liquid chromatography (HPLC). The result obtained evidenced that the neurosteroids play important role in development of nicotine addiction. The result from chromatographic analysis explore that the neurosteroids in brain during nicotinic sensitization increases which may contribute to the development of dependence. Method used above for estimation can be used to investigate the pathological role of neurosteroids and to develop new therapeutics for neurological and psychiatric disorders.

KEYWORDS : Nicotinic sensitization, High Performance Liquid Chromatography, Neurosteroids, Craving.

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