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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
VALIDATION OF HPTLC METHOD FOR  MULTIVARIATE FRACTION  IN SHIKAKAI ( Acacia concinna Linn.)- FRUIT

Komal Khanpara1*,
Renuka1, Dr. V. J. Shukla1

1Pharmaceutical Chemistry Laboratory,
I.P.G.T.& R.A.,Gujarat Ayurved University,Jamnagar - 361008.Gujarat - India.
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
A simple HPTLC method has been established and validated for BRM of Shikakai  in methanolic extract of Acacia concinna Linn.-Fruit using Toluene: Ethyl acetate: Formic acid (6:2:1 v/v/v) as mobile phase.Detection and quantification w
ere performed by densitometry at ? = 595 nm. In methanolic extract and Hydrolized  extract,the content of BRM was found 0.23% and 0.37 %w/w respectively.Validatedmethod according to ICH Guidelines shows linear response over concentration range of 800 to 1600 ng. The LOD and LOQ values were found to be 12.1 ng,36.68 ng respectively. This method was found precise, accurate, specific and recoverable.

KEYWORDS : HPTLC, BRM of Shikakai, ICH guidelines, Validation etc.


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