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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
FORMULATION OPTIMIZATION AND IN VITRO RELEASE STUDY OF DIDANOSINE LOADED BOVINE SERUM ALBUMIN NANOPARTICLES

Kavita Dua
1*, PiyushTrivedi1

1School of Pharmaceutical Sciences,
Rajiv Gandhi Technical University,
Airport Bypass Road, Gandhi Nagar, Bhopal-462 036, India
     
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
Albumin is an attractive macromolecular carrier and widely used to prepare nanospheres and nanocapsules, due to its availability in pure form and its biodegradability, nontoxicity and nonimmmunogenicity.
In the present work Didanosine loaded bovine serum albumin nanoparticles were prepared by desolvation method. Optimization of the formulations was done by selecting four process variables: stirring speed, pH of solution, polymer concentration and amount of cross linking agent (glutaraldehyde). The particle sizes of  nanoparticles were found in the range of 50.5-109.1 nm, zeta potential -23.5, drug loading was 36.63 g per mg of nanoparticles, entrapment efficiency was 80.87%, and % cumulative release was 82.13% after 48 hrs.

KEYWORDS : Didanosine, Nanoparticles, Bovine Serum Albumin, Glutaraldehyde

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