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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
EVALUATION OF HEPATOPROTECTIVE EFFECT OF AVERRHOA CARAMBOLA  L.  LEAVES ON ANTI-TUBERCULAR DRUGS INDUCED HEPATOTOXICITY

B Jyothi*1,
S. Mohana lakshmi2, K. Anitha1

1
Krishna Teja Pharmacy College,
Chadalawada Nagar, Renigunta road,
Tirupathi-517506, Chittoor (DIST), A.P, India.
2Sree Vidyanikehan College of  Pharmacy, Sree Sainath
Nagar, A.Rangampet, Tirupathi-517102, Chittoor (dist), A.P, India.
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
The aim of the present study is to evaluate the hepatoprotective effect of ethanolic extract of AverrhoacarambolaL.leaves on anti-tubercular drugs induced hepatotoxicity. Hepatotoxicity is induced in albino rats by combination of anti-tubercular drugs such as H (27 mg/kg p.o.), R (40 mg/kg p.o.), Z (66 mg/kg p.o.) and E (53 mg/kg) for 35 days. Silymarin (100 mg/kg p.o.) is taken as the standard drug. Ethanolic extract of Averrhoa carambola L. 250mg/kg and 500 mg/kg administration orally for 35 days with one hour prior administration of anti-tubercular drugs. Among 250 & 500 mg/kg, 500mg/kg showed significant reduction in serum liver marker enzymes like AST, ALT, ALP, total bilirubin and total cholesterol, whereas increase in the levels of total HDL, when compared to control. Invivo antioxidant studies, we found a significant increase in the levels of SOD, CAT, GSH, GPx and GRx whereas marked decrease in the levels of lipid peroxidation levels as compared to control. Histopathological examination of the liver sections treated with ethanolic extract of Averrhoa carambola L. 250 mg/kg and 500 mg/kg showed significant reduction in liver cell necrosis and inflammation in the centrilobular region compared to hepatic control. The above results suggest that Averrhoa carambola L. leaves showed protective effect on anti-tubercular drugs induced hepatotoxicity.

KEYWORDS : Averrhoa carambola L. leaves, anti-tubercular drugs, hepatotoxicity, liver marker enzymes, and invivo antioxidant parameters
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