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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
PREPARATION AND OPTIMIZATION OF CLOTRIMAZOLE ANTI-DANDRUFF EMULGEL

Jinesh J. Panchal1*,

Karishma S. Patel1

1
SVKM's Shobaben Pratapbhai Patel School of Pharmacy & Technology
Management, NMIMS, Mumbai, Maharashtra, India.
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
Dandruff is a common embarrassing disorder that affects about 5% of the global population. Several antifungal agents are available in the market in different topical preparations. One such antifungal agent is Clotrimazole. Also emulgels are evolving as a promising drug delivery system. The purpose of the present investigation was to prepare an anti-dandruff emulgel of clotrimazole using gelling agents like Carbopol 940, Lutrol F127 and HPMC K4M in various concentrations. Mentha Oil was used as a permeation enhancer. All the formulations were evaluated for physical appearance, pH, spreadability, viscosity, drug content, invitro release, antifungal activity and skin irritation studies. Out of all the formulations, F3 showed the highest drug release and drug content and the best antifungal activity along with good spreadability and extrudability. So it can be concluded that the formulation F3 containing gelling agent Lutrol F127 possesses the best anti-dandruff activity of all the formulations.

KEYWORDS : Dandruff, Clotrimazole, emulgel, Carbopol, Lutrol F127, HPMC K4M.


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