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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright © 2009  by "International Journal of Pharmaceutica Research and Development"  ∑  All Rights reserved  ∑  E-Mail: info@ijprd.com
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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
EVALUATION OF NEUROPROTECTIVE POTENTIAL OF MENTHA SPICATA IN REVERSAL OF NEUROTOXICITY INDUCED COGNITIVE IMPAIRMENT

Shamal Dhamnikar1*,

Manish Gupta1, Amit Page1

*School of Pharmacy & Technology Management,
SVKMíS NarseeMonjee Institute of Management Studies (NMiMS),
Shirpur, MH, India

May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
The cognitive impairment seen in epileptics may be a consequence of either the epiptogenic process alone or it could manifest on account of the use of antiepileptic drugs that cause cognitive impairment as an adverse effect or both. Thus there is need for newer drugs that can suppress the epileptogenesis by acting to prevent the development of cognitive impairment. Mentha spicata,an Indian medicinal plant has marked antioxidant property. The effect of seven days pretreatment of 500mg/kg of alcoholic extract and in combination of 12.5 mg/kg Phenytoin and 500mg/kg extract, and 25 mg/kg Phenytoin and 500mg/kg extract.administered orally to mice was evaluated on MES induced seizure, cognitive deficit. Mentha spicata did not shown significant protection against MES (maximal electro shock) induced convulsions. When only extract was administered there was
Tonic extension phase was observed and insignificant decrease of recovery. This result indicates that ethanolic extract of Mentha spicata does not possess anti-epileptic activity and it canít protect animal from MES. The p value one way ANOVA followed by Dunnettís test in MES, p< 0.0001. From the Elevated plus maze model and passive avoidance it may be concluded that, the Ethanolic extract of Mentha spicata does not show the significant antiepileptic activity and extract does not also have significant effect on AED induced cognitive impairment.

KEYWORDS :
Antiepileptic; Mentha spicata; Leaves; Maximal electroshock; Cooks pole      climbing; Elevated plus maze.
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