Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
Welcome to "International Journal of Pharmaceutical Research and Development"  i.e. "IJPRD"
HOW TO PREPARE   
YOUR PAPER
What's New | Feedback | Copyright and Disclaimer
TODAY IS
Abstract Content
Model Abstract
Summary Content
Model Summary

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
Welcome to "International Journal of Pharmaceutical Research and Development"  i.e. "IJPRD"
HOW TO PREPARE   
YOUR PAPER
What's New | Feedback | Copyright and Disclaimer
Online Since : March 2009
TODAY IS
Abstract Content
Model Abstract
Summary Content
Model Summary

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
DEVELOPMENT AND EVALUATION OF IMATINIB MESYLATE MICROSPHERES BY CHEMICAL CROSS LINKING METHOD USING CHITOSAN

S.P. Senthil*1,
Nagesh R. Sandu2, K.L. Senthilkumar2

1The Erode College of Pharmacy & Research,Veppampalayam, Erode.
2Padmavathi College of Pharmacy and Research Institute, Dharmapuri.
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
Chitosan (CS) microspheres containing Imatinib mesylate were prepared by chemical cross linking method. The incorporation efficiency of the prepared microspheres ranged between 76 % and 88%. The effect of Chitosan concentration, cross-linking ions and drying conditions was evaluated with respect to entrapment efficiency, particle size, surface characteristics and In vitro release behaviour. Infrared spectroscopic study confirmed the drug-polymer compatibility. Differential scanning calorimetric analysis revealed that the drug was molecularly dispersed in the CS microsphere matrices. Scanning electron microscopic study of microspheres showed the smooth surface due to higher concentration of drug molecules dispersed at molecular level in the chitosan matrices. The mean particle size and entrapment efficiency were found to be varied by changing various formulation parameters. The in vitro release profile could be altered significantly by changing various concentration parameters to give a sustained release of drug from the microspheres. The kinetic modeling of the release data indicate that imatinib release from the chitosan microspheres follow anomalous transport mechanism after an initial lag period when the drug release mechanism was found to be Non- Fickian diffusion controlled.


KEYWORDS :
Chitosan, microspheres, Imatinib mesylate, Chemical cross linking.
[ Full Text - PDF ]
Share This Article on Social Networking's or You can invite friends to this Article.  !!